Which of the following is true about Noncomedo Ductal Carcinoma in situ?

Which of the following is true about Noncomedo Ductal Carcinoma in situ?

• A. More aggressive than Comedo type
• B. Associated with calcifications
• C. No necrosis and less dead cells
• D. Commonly found in males over 60

Answer: (C)

Noncomedo Ductal Carcinoma in situ (DCIS) is characterized by the absence of necrosis and typically shows fewer dead cells compared to its comedocarcinoma counterpart. In noncomedo DCIS, the tumor cells are confined to the ducts of the breast without invasion into the surrounding stromal tissue, which contributes to a more organized appearance with lower levels of necrosis. This makes it less aggressive in terms of growth potential when compared to the comedo type, which often exhibits significant necrosis, high-grade tumor characteristics, and a more aggressive behavior. Furthermore, while calcifications can be associated with various types of DCIS, they are more commonly related to the comedo subtype, which is characterized by central necrosis and can lead to calcification clusters visible on imaging studies. Noncomedo DCIS does not have a strong association with older age in males. In fact, DCIS itself is predominantly diagnosed in females, and its occurrence in males is quite rare, making options about demographics less relevant in this context. Thus, focusing on the histological features, the absence of necrosis, and the presence of viable tumor cells defines the characteristics of Noncomedo DCIS effectively.

Noncomedo Ductal Carcinoma in situ (DCIS) is characterized by the absence of necrosis and typically shows fewer dead cells compared to its comedocarcinoma counterpart. In noncomedo DCIS, the tumor cells are confined to the ducts of the breast without invasion into the surrounding stromal tissue, which contributes to a more organized appearance with lower levels of necrosis.

This makes it less aggressive in terms of growth potential when compared to the comedo type, which often exhibits significant necrosis, high-grade tumor characteristics, and a more aggressive behavior. Furthermore, while calcifications can be associated with various types of DCIS, they are more commonly related to the comedo subtype, which is characterized by central necrosis and can lead to calcification clusters visible on imaging studies.

Noncomedo DCIS does not have a strong association with older age in males. In fact, DCIS itself is predominantly diagnosed in females, and its occurrence in males is quite rare, making options about demographics less relevant in this context. Thus, focusing on the histological features, the absence of necrosis, and the presence of viable tumor cells defines the characteristics of Noncomedo DCIS effectively.