What type of anemia is associated with Hereditary Spherocytosis?

What type of anemia is associated with Hereditary Spherocytosis?

• A. Transfusion-related anemia
• B. Intracorpuscular hemolytic anemia
• C. Iron-deficiency anemia
• D. Folate-deficiency anemia

Answer: (B)

Hereditary Spherocytosis is a genetic condition that results in the production of abnormally shaped red blood cells, specifically spherical rather than the typical disc shape. The spherical shape makes these red blood cells more susceptible to rupture (hemolysis) as they pass through small blood vessels, particularly in the spleen. When considering the type of anemia associated with this condition, it is important to recognize that the hemolysis occurring in Hereditary Spherocytosis is intrinsic to the red blood cells themselves, as it arises from a defect in the cell's membrane structure. This leads to a decreased lifespan of the red blood cells, resulting in an increased rate of destruction that cannot be compensated for by adequate red blood cell production. Hence, the correct classification of anemia associated with this condition is intr corpuscular hemolytic anemia. This type of anemia is characterized by the premature destruction of red blood cells originating from defects within the cells, rather than from external factors, which differentiates it from other types of anemia listed in the options.

Hereditary Spherocytosis is a genetic condition that results in the production of abnormally shaped red blood cells, specifically spherical rather than the typical disc shape. The spherical shape makes these red blood cells more susceptible to rupture (hemolysis) as they pass through small blood vessels, particularly in the spleen.

When considering the type of anemia associated with this condition, it is important to recognize that the hemolysis occurring in Hereditary Spherocytosis is intrinsic to the red blood cells themselves, as it arises from a defect in the cell's membrane structure. This leads to a decreased lifespan of the red blood cells, resulting in an increased rate of destruction that cannot be compensated for by adequate red blood cell production. Hence, the correct classification of anemia associated with this condition is intr corpuscular hemolytic anemia.

This type of anemia is characterized by the premature destruction of red blood cells originating from defects within the cells, rather than from external factors, which differentiates it from other types of anemia listed in the options.