What is characteristic of choriocarcinoma?

What is characteristic of choriocarcinoma?

• A. Large cells with irregular hyperchromatic nuclei
• B. Presence of Hurtle cells
• C. Intraductal papilloma formation
• D. Solid cystic mass in the ovaries

Answer: (A)

Choriocarcinoma is a type of malignant neoplasm that originates from trophoblastic tissue, which is part of the placenta. One of the hallmark features of choriocarcinoma is the presence of large tumor cells that exhibit irregular and hyperchromatic nuclei. This characteristic is due to the tumor's highly aggressive nature and its rapid proliferation, which results in significant nuclear atypia. Hyperchromatic nuclei indicate increased DNA content and are often seen in malignant cells. The presence of Hurtle cells is more commonly associated with certain types of thyroid neoplasms rather than choriocarcinoma. Intraductal papilloma formation pertains to breast lesions and does not relate to choriocarcinoma, as this type of tumor usually presents as a solid mass rather than forming a papillary structure. Lastly, while choriocarcinoma can metastasize to the ovaries and might be seen as a mass, it is not typically described as presenting as a solid cystic mass in the ovaries; rather, it is usually characterized by its solid nature and specific cellular composition. So, option A accurately reflects the distinct cellular features associated with choriocarcinoma.

Choriocarcinoma is a type of malignant neoplasm that originates from trophoblastic tissue, which is part of the placenta. One of the hallmark features of choriocarcinoma is the presence of large tumor cells that exhibit irregular and hyperchromatic nuclei. This characteristic is due to the tumor's highly aggressive nature and its rapid proliferation, which results in significant nuclear atypia. Hyperchromatic nuclei indicate increased DNA content and are often seen in malignant cells.

The presence of Hurtle cells is more commonly associated with certain types of thyroid neoplasms rather than choriocarcinoma. Intraductal papilloma formation pertains to breast lesions and does not relate to choriocarcinoma, as this type of tumor usually presents as a solid mass rather than forming a papillary structure. Lastly, while choriocarcinoma can metastasize to the ovaries and might be seen as a mass, it is not typically described as presenting as a solid cystic mass in the ovaries; rather, it is usually characterized by its solid nature and specific cellular composition. So, option A accurately reflects the distinct cellular features associated with choriocarcinoma.